Usefulness of high molecular weight adiponectin-leptin ratio as a predictor of all-cause mortality in dialysis patients

A recent study has shown that the accumulation of visceral fat is increased in dialysis patients irrespective of BMI. We reported a negative relationship between the visceral fat area (VFA) and the log-transformed values of the ratio of high molecular weight adiponectin to leptin (h-Adipo/Lep ratio) in dialysis patients. In this study, to clarify the association between all-cause mortality and visceral obesity, we investigated whether or not VFA and the h-Adipo/Lep ratio were predictors of survival. The study included 120 dialysis patients during a 53-month follow-up period. We measured serum high molecular weight adiponectin and leptin concentrations, and visceral fat area by abdominal CT. Log-transformed h-Adipo/Lep ratio was inversely related to the visceral fat area for all subjects (r=-0.624, p0.65 group was 65.1%, which was significantly lower than that in the h-Adipo/Lep ratio0.65, the survival rate in the VFA>75cm2 group was significantly lower than that in the VFA