Experimental investigation of a continuous albumin purification system

We developed a continuous albumin purification system (CAPS) and an albumin-containing dialysate regenerating system. We investigated the clinical application of the systems using bilirubin as an index, and investigated the transfer of endotoxin into blood during treatment. Removal of indoxyl sulfate and cisplatin, a protein-binding toxin, by CAPS was also assessed. Since it was confirmed in these experiments that the dialysate regenerating system was useful and that endotoxin was not transferred into the blood, CAPS appears to be a very safe system in clinical practice. It was also confirmed that indoxyl sulfate could be removed, although cisplatin could not be removed.