Nafamostat mesilate induced eosinophilia; mechanism of eosinophilia and its relationship to IL-2 and IL-3

Marked eosinophilia induced by nafamostat mesilate (Futhan®; FUT), a serine-protease inhibitor, was recently reported in a hemodialysis patient. However the mechanism and the pattern of allergic reaction are currently unknown. Here we report a case of a 56-year-old man on hemodialysis who showed marked eosinophilia (13000/μl) induced by FUT. According to challenge test results, the eosinophilia did not occur in the early phases of drug usage. However, marked eosinophilia developed with repetitive use of FUT. There was a positive correlation between the incidence of drug use and the eosinophil counts (Y=1.849+0.061X, R2=0.95, p