The effect on the rate and amount of removal of various substances by changes in dialysis flow, dialysis time and blood flow

The effect on the rate and amount of removal of low molecular weight substances (UN, Cr, UA, iP), middle molecular weight substances (peak-2a) and low molecular proteins (β2-MG) following changes in dialysis flow, dialysis time and blood flow were examined in hemodialysis patients. In addition the effect on the KT/V of urea and TACBUN by changes in blood flow was examined. The removal rate of all substances studied did not differ between a 500ml/min rate of dialysate flow and a 400ml/min rate of dialysate-flow, nor between four or five hour hemodialysis. The total removal amounts of all substances tested for, at a dialysate flow of 500ml/min over a five hour hemodialysis period were higher than at a dialysate flow of 400ml/min over a four hour period of hemodialysis. The KT/V of urea and TACBUN at a blood-flow rate of 280ml/min were higher than at a blood flow rate of 220ml/min, but remained within normal limits. From these results, we concluded that a rate of dialysis flow of 500ml/min was more effective than 400ml/min for the removal amount of various substances, and that five-hour-hemodialysis was more effective than hemodialysis over a four hour period for the removal amount.