Relationship between the activity of superoxide anion production by neutrophils and plasma TNF-α and IL-8 levels in hemodialysis patients
Relationships between maximal superoxide anion production by neutrophils and plasma tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) were studied in patients during hemodialysis. The subjects were 28 hemodialysis patients (HD-Ps) at our hospital and 21 persons undergoing intensive health scr...
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| Veröffentlicht in: | Nihon Toseki Igakkai Zasshi 1994/01/28, Vol.27(1), pp.41-46 |
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| container_title | Nihon Toseki Igakkai Zasshi |
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| creator | Shiwa, Masaaki Yokota, Takehiko Yokota, Kinya Matsuura, Tatsuo |
| description | Relationships between maximal superoxide anion production by neutrophils and plasma tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) were studied in patients during hemodialysis. The subjects were 28 hemodialysis patients (HD-Ps) at our hospital and 21 persons undergoing intensive health screening, who served as the controls (CTs). The level of neutrophil superoxide anion production was determined by the chemiluminescence method using cypridina the luciferin analogs CLA or FCLA as probes. Plasma TNF-α and IL-8 concentrations were determined by ELISA. Neutrophil superoxide anion-producing activity was significantly (p |
| doi_str_mv | 10.4009/jsdt.27.41 |
| format | Article |
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The subjects were 28 hemodialysis patients (HD-Ps) at our hospital and 21 persons undergoing intensive health screening, who served as the controls (CTs). The level of neutrophil superoxide anion production was determined by the chemiluminescence method using cypridina the luciferin analogs CLA or FCLA as probes. Plasma TNF-α and IL-8 concentrations were determined by ELISA. Neutrophil superoxide anion-producing activity was significantly (p<0.01) higher in the HD-Ps than in the CTs. Plasma TNF-α and IL-8 concentrations were also significantly (p<0.001; p<0.0025) higher in the HD-Ps. At 15min after the start of hemodialysis, neutrophil superoxide anion-producing activity was significantly (p<0.01) higher than the pre-hemodialysis level. At the end of hemodialysis, activity had decreased somewhat but was still higher (p<0.05) than the pre-hemodialysis level. No significant changes were detected in plasma TNF-α or IL-8 concentrations during hemodialysis. The superoxide anion-producing activity of neutrophils increased dose-dependently in response to priming with recombinant human TNF-α and recombinant human IL-8. When the neutrophils of healthy persons were pre-incubated with the plasma of HD-Ps and CTs, their superoxide anion-producing activity was clearly (p<0.01) higher after pre-incubation with HD-P plasma. From the above findings, we conclude that neutrophil superoxide anion production is not directly induced by TNF-α or IL-8 but via the priming effect of the cytokines. These high cytokine levels thus appear to be due to active oxygen production in hemodialysis patients, since they are in a state in which superoxide anions are likely to be generated due to activation of serum complement, etc., as a result of hemodialysis therapy.]]></description><identifier>ISSN: 1340-3451</identifier><identifier>EISSN: 1883-082X</identifier><identifier>DOI: 10.4009/jsdt.27.41</identifier><language>eng</language><publisher>The Japanese Society for Dialysis Therapy</publisher><subject>hemodialysis ; interleukin-8 ; superoxide anion production ; tumor necrosis factor-α</subject><ispartof>Nihon Toseki Igakkai Zasshi, 1994/01/28, Vol.27(1), pp.41-46</ispartof><rights>The Japanese Society for Dialysis Therapy</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,4022,27922,27923,27924</link.rule.ids></links><search><creatorcontrib>Shiwa, Masaaki</creatorcontrib><creatorcontrib>Yokota, Takehiko</creatorcontrib><creatorcontrib>Yokota, Kinya</creatorcontrib><creatorcontrib>Matsuura, Tatsuo</creatorcontrib><title>Relationship between the activity of superoxide anion production by neutrophils and plasma TNF-α and IL-8 levels in hemodialysis patients</title><title>Nihon Toseki Igakkai Zasshi</title><addtitle>Nihon Toseki Igakkai Zasshi</addtitle><description><![CDATA[Relationships between maximal superoxide anion production by neutrophils and plasma tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) were studied in patients during hemodialysis. The subjects were 28 hemodialysis patients (HD-Ps) at our hospital and 21 persons undergoing intensive health screening, who served as the controls (CTs). The level of neutrophil superoxide anion production was determined by the chemiluminescence method using cypridina the luciferin analogs CLA or FCLA as probes. Plasma TNF-α and IL-8 concentrations were determined by ELISA. Neutrophil superoxide anion-producing activity was significantly (p<0.01) higher in the HD-Ps than in the CTs. Plasma TNF-α and IL-8 concentrations were also significantly (p<0.001; p<0.0025) higher in the HD-Ps. At 15min after the start of hemodialysis, neutrophil superoxide anion-producing activity was significantly (p<0.01) higher than the pre-hemodialysis level. At the end of hemodialysis, activity had decreased somewhat but was still higher (p<0.05) than the pre-hemodialysis level. No significant changes were detected in plasma TNF-α or IL-8 concentrations during hemodialysis. The superoxide anion-producing activity of neutrophils increased dose-dependently in response to priming with recombinant human TNF-α and recombinant human IL-8. When the neutrophils of healthy persons were pre-incubated with the plasma of HD-Ps and CTs, their superoxide anion-producing activity was clearly (p<0.01) higher after pre-incubation with HD-P plasma. From the above findings, we conclude that neutrophil superoxide anion production is not directly induced by TNF-α or IL-8 but via the priming effect of the cytokines. These high cytokine levels thus appear to be due to active oxygen production in hemodialysis patients, since they are in a state in which superoxide anions are likely to be generated due to activation of serum complement, etc., as a result of hemodialysis therapy.]]></description><subject>hemodialysis</subject><subject>interleukin-8</subject><subject>superoxide anion production</subject><subject>tumor necrosis factor-α</subject><issn>1340-3451</issn><issn>1883-082X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNo9kEtOwzAQhi0EEqWw4QReI6X4lTReoopHpQokVCR2kWNPias0iWy3kCtwGy7CmXBa1M08_vlmRjMIXVMyEYTI27U3YcKmE0FP0IjmOU9Izt5PY8wFSbhI6Tm68H5NSCZTSkbo-xVqFWzb-Mp2uITwCdDgUAFWOtidDT1uV9hvO3DtlzVRbiKMO9earR76cNnjBrbBtV1lax_rBne18huFl88Pye_PXpkvkhzXsINI2AZXsGmNVXXvrcdd3A9N8JfobKVqD1f_fozeHu6Xs6dk8fI4n90tEh0PogmVWmU812QqjSlLkEJIxtM8z2JWMk0YZYZRkgmuxSBRI_mUCEVMyjgYPkY3h7natd47WBWdsxvl-oKSYvhiMXyxYNNC0AjPDvDaB_UBR1S5YHUNe5RKKQacHoygx6qulCug4X-4ZoF_</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Shiwa, Masaaki</creator><creator>Yokota, Takehiko</creator><creator>Yokota, Kinya</creator><creator>Matsuura, Tatsuo</creator><general>The Japanese Society for Dialysis Therapy</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1994</creationdate><title>Relationship between the activity of superoxide anion production by neutrophils and plasma TNF-α and IL-8 levels in hemodialysis patients</title><author>Shiwa, Masaaki ; Yokota, Takehiko ; Yokota, Kinya ; Matsuura, Tatsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1881-19ca638c079ddbbe9449235886dbbb2c0212d210643c4dbbb1d93704a0d523ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>hemodialysis</topic><topic>interleukin-8</topic><topic>superoxide anion production</topic><topic>tumor necrosis factor-α</topic><toplevel>online_resources</toplevel><creatorcontrib>Shiwa, Masaaki</creatorcontrib><creatorcontrib>Yokota, Takehiko</creatorcontrib><creatorcontrib>Yokota, Kinya</creatorcontrib><creatorcontrib>Matsuura, Tatsuo</creatorcontrib><collection>CrossRef</collection><jtitle>Nihon Toseki Igakkai Zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shiwa, Masaaki</au><au>Yokota, Takehiko</au><au>Yokota, Kinya</au><au>Matsuura, Tatsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between the activity of superoxide anion production by neutrophils and plasma TNF-α and IL-8 levels in hemodialysis patients</atitle><jtitle>Nihon Toseki Igakkai Zasshi</jtitle><addtitle>Nihon Toseki Igakkai Zasshi</addtitle><date>1994</date><risdate>1994</risdate><volume>27</volume><issue>1</issue><spage>41</spage><epage>46</epage><pages>41-46</pages><issn>1340-3451</issn><eissn>1883-082X</eissn><abstract><![CDATA[Relationships between maximal superoxide anion production by neutrophils and plasma tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) were studied in patients during hemodialysis. The subjects were 28 hemodialysis patients (HD-Ps) at our hospital and 21 persons undergoing intensive health screening, who served as the controls (CTs). The level of neutrophil superoxide anion production was determined by the chemiluminescence method using cypridina the luciferin analogs CLA or FCLA as probes. Plasma TNF-α and IL-8 concentrations were determined by ELISA. Neutrophil superoxide anion-producing activity was significantly (p<0.01) higher in the HD-Ps than in the CTs. Plasma TNF-α and IL-8 concentrations were also significantly (p<0.001; p<0.0025) higher in the HD-Ps. At 15min after the start of hemodialysis, neutrophil superoxide anion-producing activity was significantly (p<0.01) higher than the pre-hemodialysis level. At the end of hemodialysis, activity had decreased somewhat but was still higher (p<0.05) than the pre-hemodialysis level. No significant changes were detected in plasma TNF-α or IL-8 concentrations during hemodialysis. The superoxide anion-producing activity of neutrophils increased dose-dependently in response to priming with recombinant human TNF-α and recombinant human IL-8. When the neutrophils of healthy persons were pre-incubated with the plasma of HD-Ps and CTs, their superoxide anion-producing activity was clearly (p<0.01) higher after pre-incubation with HD-P plasma. From the above findings, we conclude that neutrophil superoxide anion production is not directly induced by TNF-α or IL-8 but via the priming effect of the cytokines. These high cytokine levels thus appear to be due to active oxygen production in hemodialysis patients, since they are in a state in which superoxide anions are likely to be generated due to activation of serum complement, etc., as a result of hemodialysis therapy.]]></abstract><pub>The Japanese Society for Dialysis Therapy</pub><doi>10.4009/jsdt.27.41</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nihon Toseki Igakkai Zasshi, 1994/01/28, Vol.27(1), pp.41-46 |
| issn | 1340-3451 1883-082X |
| language | eng |
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| source | J-STAGE Free |
| subjects | hemodialysis interleukin-8 superoxide anion production tumor necrosis factor-α |
| title | Relationship between the activity of superoxide anion production by neutrophils and plasma TNF-α and IL-8 levels in hemodialysis patients |
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