Study on the pharmacokinetics of gabexate mesilate (GM) and its metabolites during hemodialysis (the second report)

The pharmacokinetics of gabexate methylate (GM) (five consecutive administrations) during hemodialysis were studied by measuring the plasma levels of its metabolites (GCA, EPHB, PHB, and glucuronide conjugate of EPHB and PHB). Plasma levels of GM metabolites did not change after the third GM hemodia...

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Veröffentlicht in:	Journal of Japanese Society for Dialysis Therapy 1988/01/28, Vol.21(1), pp.47-54
Hauptverfasser:	Ishiguro, Motoyuki, Yasue, Takao, Watanabe, Sachiro, Sawada, Shigeki, Endo, Toyohiro, Furuta, Akiharu, Sawada, Masafumi, Ishido, Masatsune, Nakausa, Masako, Miyamoto, Shigetoshi
Format:	Artikel
Sprache:	jpn
Schlagworte:	EPHB (ethyl-p-hydroxybenzoate) GCA (guanidinocaproic acid) GM (gabexate mesilate) hemodialysis PHB (p-hydroxybenzoic acid)
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Beschreibung
Zusammenfassung:	The pharmacokinetics of gabexate methylate (GM) (five consecutive administrations) during hemodialysis were studied by measuring the plasma levels of its metabolites (GCA, EPHB, PHB, and glucuronide conjugate of EPHB and PHB). Plasma levels of GM metabolites did not change after the third GM hemodialysis. They decreased after GM had been replaced by heparin, and GM metabolites were no longer detected in plasma after one month.
ISSN:	0911-5889 1884-6211
DOI:	10.4009/jsdt1985.21.47