Studies on sequential changes of lipid metabolism in long-term CAPD patients

Sequential changes in serum lipids, apoprotein and post-dextran sulfate lipolytic activity were studied in long-term CAPD patients. Hypertriglyceridemia was temporally accelerated after 7-12 months of CAPD, but this acceleration was gradually corrected by continuation of CAPD over 2 years. HDL-cholesterol increased slightly after 7-12 months of CAPD, but this was not statistically significant. LCAT activity gradually decreased during long-term CAPD and apo-A1, A2 decreased after 37 months of CAPD. Apo-B and apo-E showed no significant changes during CAPD. The changes in these various parameters were considered responsible for the early development of atherosclerosis. However, it is considered that a less marked change in apo C2/C3 ratio and a slight increase in LPL, HTGL activity as a result of long-term CAPD may protect against atherosclerosis in CAPD patients. Further studies will thus be needed to overcome these problems.