Clearance of Paraquat using various kinds of hemopurification

When we treat patients with acute Paraquat poisoning, we usually use direct hemoperfusion which continues for many hours. However, this method often causes side effects such as a decrease in platelet thrombocytes or coagulation. This cannot be avoided, since it is a peculiarity of direct hemoperfusion. I therefore measured and compared the clearance of Paraquat by means of direct hemoperfusion, hemodialysis, hemofiltration and plasmaperfusion. It was found that direct hemoperfusion was the best way to clear paraquat at 50ppm or 125ppm. The second best way was hemodialysis. Details are tabulated as follows. Direct hemoperfusion 196±3.1ml/min (50ppm), 194±2.9ml/min (125ppm), hemodialysis 54.1±3.2ml/min (50ppm), 101.4±5.2ml/min (125ppm), plasmaperfusion 65.2±7.2ml/min (50ppm), 98.1±10.4ml/min (125ppm), hemofiltration 53.1±7.2ml/min (50ppm), 85.6±8.2ml/min (125ppm). It therefore seems possible to substitute hemodialysis for direct hemoperfusion during the long period when it is carried out. When the quantity of Paraquat adsorbed by 1g of charcoal was measured, it was found to be 17mg. We can theretore deduce the effective time of direct hemoperfusion from the Paraquat concentration in the blood.