Effects of salt intake on serum Na+ concentration and body fluid distribution in dialysis patients

The changes in serum [Na+] concentration and transcellular body fluid distribution during interdialysis period were simulated. It may be important to restrict salt intake in patients undergoing high Na+ hemodialysis in order to keep the long term effects without positive sodium balance. The combined application of our models for both intradialysis and interdialysis is very useful to draw a whole picture of sodium and water metabolism in dialysis patients.