Basic fibroblast growth factor reduces infarct size after experimental ischemia in a rat model
The purpose of the present study was to ascertain whether or not basic fibroblast growth factor (bFGF) caused contraction of cerebral infarcts in rats with experimental ischemia. We permanently occluded the left middle cerebral artery (MCAO) of 21 Sprague-Dawley rats, and immediately infused bFGF (1...
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| Veröffentlicht in: | Japanese Journal of Stroke 1994/06/25, Vol.16(3), pp.186-190 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | jpn |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | The purpose of the present study was to ascertain whether or not basic fibroblast growth factor (bFGF) caused contraction of cerebral infarcts in rats with experimental ischemia. We permanently occluded the left middle cerebral artery (MCAO) of 21 Sprague-Dawley rats, and immediately infused bFGF (100 ng in physiological saline (PS)) and PS intraarterially in the bFGF and control groups, respectively. The cerebral infarct size determined at 24 hours after MCAO in the bFGF-treated group was significantly decreased (p |
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| ISSN: | 0912-0726 1883-1923 |
| DOI: | 10.3995/jstroke.16.186 |