STUDIES ON THE HUMAN MONOCYTE ANTIGEN

We studied a random sample of Japanese and compared both Japanese and German monocyte antigen frequencies and performed a segregation analysis in Japanese families. In Japanese, the following gene frequencies were established: 0.0801 for HMA-A1; 0.0219 for HMA-A3; 0.0096 for HMA-A6; 0.1796 for HMA-B2; 0.0024 for HMA-B4. The data of the gene frequency in German were presented by Rose (0.1340 for HMA-A1; 0.0315 for HMA-A3; 0.0096 for HMA-A6; 0.1796 for HMA-B2; 0.0024 for HMA-B4). In this comparison, the frequency for HMA-B4 in German is more than twelve times higher. For antigen HMA-A1, the Japanese is a half of the German quantity. The antigen HMA-A6 and HMA-B4 were very rare in Japanese. The results we obtained from family analysis confirmed an unambiguous autosomal, codominant inheritance of the examined HMA antigens.