STUDY OF THE SAFETY OF DONOR AND EFFICACY OF THE COLLECTED PLASMA USING MEMBRANE DONOR PLASMAPHERESIS

Because plasma is in much demand but very short in selfsufficiency in Japan, it is not enough to get source plasma derived only from 200ml or 400ml donations of whole blood. As a less expensive process whereby plasma is collected from a single voluntary donor, membrane plasmapheresis has been initiated. We investigated the safety of donating plasma and the efficacy of collected plasma by using a membrane plasmapheresis apparatus, KM8700 Kuraray. There were no complaints from 20 voluntary donors and no abnormal vital signs observed. And there was no activation of platelet, coagulation, fibrinolysis, and complement systems. The components in collected plasma showed little difference from fresh frozen plasma supplied by the Japanese Red Cross, except for a slightly low level of factor IX. We concluded that donor membrane plasmapheresis by using KM8700 Kuraray was safe and clinically useful.