Studies on biodisposition kinetics and urinary excretion of kanamycin in goats

The biodisposition kinetic and urinary excretion of kanamycin was investigated in eight normal adult female goats of beetle breed after intravenous dose of 5 mg/kg to each goat. After single intravenous administration of kanamycin in goats, the distribution half-life and biological half-life had average of 8.1 ¤ 0.893 min. and 2.87 ¤ 0.12 hrs and ranged between 4.26 to 11.61 minutes and 2.44 to 3.37 hrs respectively. The apparent volume of distribution of kanamycin in goat calculated by area method was 584.6 ¤ 34.21 mg/kg. The rate constants for kanamycin transfer across compartment 1 to 2, K12, and 2 to 1, K21, were 1.846 + 0.316 hr-1 and 3.800 ¤ 0.434 hr and ranged between 1.016 to 3.78 hr-1 and 2.45 to 5.77 hr-1 respectively. Total body clearance of kanamycin calculated on per kg basis ranged 1.79 to 3.59 ml/min/kg with an average value 2.389 ¤ 0.194 ml/min/kg. Cumulative urinary excretion as percent of total dose excreted at 12 hours was 10.266 ¤ 1.233. The studies showed variation in pharmacokinetic behavior of kanamycin in indigenous goats as compared to earlier studies.