Frequency of CYP2D63 and 4 and metabolizer phenotypes in three mestizo Peruvian populations

Wild type genotypes ( CYP2D6 ) and their allelic variants have been described in a sample of a Peruvian mestizo population. The global allele frequency was 0.015 for CYP2D6*3 and 0.051 for CYP2D6*4 . The percentages of genotypes described were 97% CYP2D6*1/*1 and 3.0% CYP2D6*1/*3 ; 90.60% for CYP2D6*1/*1 , 8.55% CYP2D6*1/*4 and 0.85% CYP2D6*4/*4 . The allelic frequencies of CYP2D6*3 in the Lima subpopulations were 0.022 and 0.010 for Junin; CYP2D6*4 of 0.048, 0.060, and 0.050 for residents of Lima, Junín, and Tacna, respectively. The Hardy-Weinberg equilibrium test for the studied population showed that both frequencies are in equilibrium, p