NAIF1 is down-regulated in gastric cancer and promotes apoptosis through the caspase-9 pathway in human MKN45 cells

Many key proteins are down-regulated or lose their function during cancer genesis and accelerate the progress of cancer. We found that nuclear apoptosis-inducing factor 1 (NAIF1) was highly expressed in normal gastric tissues but was down-regulated or lost in gastric cancer tissues (P

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Bibliographische Detailangaben
Veröffentlicht in:	Oncology reports 2011-04, Vol.25 (4), p.1117-1123
Hauptverfasser:	Luo, Qing, Zhao, Mei, Zhong, Jialing, Ma, Yiming, Deng, Guohua, Liu, Jian, Wang, Jia, Yuan, Xinghua, Huang, Changzhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - immunology Apoptosis Regulatory Proteins - metabolism Biological and medical sciences Blotting, Western Caspase 9 - metabolism Cell Cycle Cell Proliferation Down-Regulation Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques Male Medical sciences Middle Aged Neoplasm Staging Nuclear Proteins - genetics Nuclear Proteins - immunology Nuclear Proteins - metabolism Prognosis Rabbits Stomach - metabolism Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tissue Array Analysis Tumor Cells, Cultured Tumors
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Beschreibung
Zusammenfassung:	Many key proteins are down-regulated or lose their function during cancer genesis and accelerate the progress of cancer. We found that nuclear apoptosis-inducing factor 1 (NAIF1) was highly expressed in normal gastric tissues but was down-regulated or lost in gastric cancer tissues (P
ISSN:	1021-335X 1791-2431
DOI:	10.3892/or.2011.1171