Evaluation of Vitamin D Receptor Taq I (rs731236) and Bsm I (rs1544410) Gene Polymorphisms in Patients with Chronic Kidney Disease-mineral and Bone Disorder

Evaluation of Vitamin D Receptor Taq I (rs731236) and Bsm I (rs1544410) Gene Polymorphisms in Patients with Chronic Kidney Disease-mineral and Bone Disorder

BACKGROUND: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is one of the main culprits of increasing morbidity and mortality in patients with stage: 3–5 CKD. Association between Vitamin D receptor (VDR) genetic polymorphisms and CKD-MBD has been inconsistent. AIM: The aim of the study wa...

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Veröffentlicht in:Open access Macedonian journal of medical sciences 2023-01, Vol.11 (A), p.169-175
Hauptverfasser: Abdelsattar, Hoda A., Nessim, Iris G., Osman, Mona Mostafa, Elmageed, Abeer Ibrahim Abd, Waked, Emam A., Khanany, Farida M.
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Sprache:eng
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Zusammenfassung:BACKGROUND: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is one of the main culprits of increasing morbidity and mortality in patients with stage: 3–5 CKD. Association between Vitamin D receptor (VDR) genetic polymorphisms and CKD-MBD has been inconsistent. AIM: The aim of the study was to assess the association of VDR Taq I (rs731236) and Bsm I (rs1544410) gene polymorphisms with CKD; and with the development and progression of CKD-MBD. METHODS: Sixty adult (43–56 years.) Egyptian CKD-MBD male patients (CKD stages: 3–5 with estimated glomerular filtration rate
ISSN:1857-9655
1857-9655
DOI:10.3889/oamjms.2023.10631