A Clinical Study of 106 Cases of Colorectal Carcinoma Associated with Other Primary Malignancies

The clinical features of 106 patients with colorectal cancers associated with other primary malignancies were investigated in this study in order to select patients of high risk for multiple primary malignancies and to improve the therapeutic results after early detection and early treatment thereof. Clinical factors were compared between colorectal cancers with and without other primary malignancies, and between synchronous and metachronous multiple cancers. Though some clinical factors, such as sex ratio, age at diagnosis of colorectal cancer, and family history of cancer, are different between them, no clinical factors were obtained which were useful to select patients of high risk for multiple primary malignancies. The analysis with regard to the site of other primary malignancies revealed that the stomach was the most frequent site of other malignancies, and suggested that patients who had received radiation therapy for cervical cancer had high risk for the development of rectal cancer. The prognosis of patients depended on a cancer of advanced stage and the second cancer in synchronous and metachronous cancer, respectively. It is important to carry out careful examintion and follow up for detection of synchronous or metachronous cancer to improve the therapeutic results.