Genotype-Based Individual Disease Risk for the X-Linked Dominant Ancestry Pattern of Inheritance using Bayesian Approach

This study investigates the features of the inheritance patterns of X-linked dominant for different parental genotypic combinations. Risk assessment of an offspring being affected through X-linked dominant inheritance was carried out by calculating genotypic probability by the frequentist (conventional probabilistic) and the Bayesian approach. The family history containing the necessary pedigree information of four different families’ for 45 individuals’ genetic heritage simulated data was used here. The two ancestry patterns each originated from two different families were initially used for the pedigree analysis. Then, five possible ancestry patterns were identified from these pedigrees based on parental genotype combinations. Pedigree analysis was done for all these cases, and the genotypic probabilities were calculated by the conventional probabilistic and the Bayesian approach. Usually, affected mothers with different genotypes were responsible for different inheritance patterns. The probability (risk) of being affected were observed to be different based on the individual genotype combination in both frequentist and Bayesian approach.