Studies on the Distribution of Colloidal Radioactive Gold (198Au), Chromic Phosphate (Cr32PO4) and Lutecium Chloride (177LuCl3) Administered in Normal and Ascites Tumor Bearing Mice

Direct intercomparison of the distribution of colloidal 198Au, Cr32PO4 and 177LuC13 administered in normal and Ehrlich ascites tumor bearing mice was made under identical condition, and the results obtained were reported in detail including autoradiographic findings. Following intraperitoneal administration in normal mice the translocation of the Cr 32PO4 into liver was the least among the three compounds. Following intraperitoneal administration in the Ehrlich ascites tumor bearing mice the translocation into the liver was less as compared with that in normal mice. Thus the difference of distribution of colloidal substance between normal and ascites tumor bearing mice was demonstrated. Autoradiographic findings disclose a considerable amount of deposition of the colloidal substance in the milky spot of the omentum as well as in free macrophages and on the peritoneal membrane.