Asymmetric desymmetrization of meso -diols by C 2 -symmetric chiral 4-pyrrolidinopyridines

Asymmetric desymmetrization of meso -diols by C 2 -symmetric chiral 4-pyrrolidinopyridines

In this work we developed C 2 -symmetric chiral nucleophilic catalysts which possess a pyrrolidinopyridine framework as a catalytic site. Some of these organocatalysts effectively promoted asymmetric desymmetrization of meso -diols via enantioselective acylation.

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Veröffentlicht in:Beilstein journal of organic chemistry 2012-10, Vol.8, p.1778-1787
Hauptverfasser: Schedel, Hartmut, Kan, Keizo, Ueda, Yoshihiro, Mishiro, Kenji, Yoshida, Keisuke, Furuta, Takumi, Kawabata, Takeo
Format: Artikel
Sprache:eng
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Zusammenfassung:In this work we developed C 2 -symmetric chiral nucleophilic catalysts which possess a pyrrolidinopyridine framework as a catalytic site. Some of these organocatalysts effectively promoted asymmetric desymmetrization of meso -diols via enantioselective acylation.
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.8.203