Achiral bis-imine in combination with CoCl 2 : A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol

Achiral bis-imine in combination with CoCl 2 : A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol

A bis-imine (prepared via a new FeCl 3 -based method) in combination with CoCl 2 facilitated lipase-mediated acetylation of the ( R )-isomer of a racemic benzylic secondary alcohol with 91% ee s . The methodology was used for the preparation of the known drug rivastigmine.

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Veröffentlicht in:Beilstein journal of organic chemistry 2010-12, Vol.6, p.1174-1179
Hauptverfasser: Arunkumar, K, Reddy, M Appi, Kumar, T Sravan, Kumar, B Vijaya, Chandrasekhar, K B, Kumar, P Rajender, Pal, Manojit
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container_title Beilstein journal of organic chemistry
container_volume 6
creator Arunkumar, K
Reddy, M Appi
Kumar, T Sravan
Kumar, B Vijaya
Chandrasekhar, K B
Kumar, P Rajender
Pal, Manojit
description A bis-imine (prepared via a new FeCl 3 -based method) in combination with CoCl 2 facilitated lipase-mediated acetylation of the ( R )-isomer of a racemic benzylic secondary alcohol with 91% ee s . The methodology was used for the preparation of the known drug rivastigmine.
doi_str_mv 10.3762/bjoc.6.134
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title Achiral bis-imine in combination with CoCl 2 : A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol
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