Achiral bis-imine in combination with CoCl 2 : A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol

A bis-imine (prepared via a new FeCl 3 -based method) in combination with CoCl 2 facilitated lipase-mediated acetylation of the ( R )-isomer of a racemic benzylic secondary alcohol with 91% ee s . The methodology was used for the preparation of the known drug rivastigmine.

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Bibliographische Detailangaben
Veröffentlicht in:	Beilstein journal of organic chemistry 2010-12, Vol.6, p.1174-1179
Hauptverfasser:	Arunkumar, K, Reddy, M Appi, Kumar, T Sravan, Kumar, B Vijaya, Chandrasekhar, K B, Kumar, P Rajender, Pal, Manojit
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A bis-imine (prepared via a new FeCl 3 -based method) in combination with CoCl 2 facilitated lipase-mediated acetylation of the ( R )-isomer of a racemic benzylic secondary alcohol with 91% ee s . The methodology was used for the preparation of the known drug rivastigmine.
ISSN:	1860-5397 1860-5397
DOI:	10.3762/bjoc.6.134