Synthesis of trifluoromethylated 2 H -azirines through Togni reagent-mediated trifluoromethylation followed by PhIO-mediated azirination

Synthesis of trifluoromethylated 2 H -azirines through Togni reagent-mediated trifluoromethylation followed by PhIO-mediated azirination

The reaction of enamine compounds with the Togni reagent in the presence of CuI afforded β-trifluoromethylated enamine intermediates, which were converted directly to biologically interesting trifluoromethylated 2 -azirines by an iodosobenzene (PhIO)-mediated intramolecular azirination in a one-pot...

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Veröffentlicht in:Beilstein journal of organic chemistry 2018-06, Vol.14, p.1452-1458
Hauptverfasser: Sun, Jiyun, Zhen, Xiaohua, Ge, Huaibin, Zhang, Guangtao, An, Xuechan, Du, Yunfei
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Sprache:eng
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Zusammenfassung:The reaction of enamine compounds with the Togni reagent in the presence of CuI afforded β-trifluoromethylated enamine intermediates, which were converted directly to biologically interesting trifluoromethylated 2 -azirines by an iodosobenzene (PhIO)-mediated intramolecular azirination in a one-pot process.
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.14.123