Renoprotective Effects of PLGA Nanoparticles Loaded with Vitamin E in Wistar Rats, on Hypercaloric Diet

Obesity is associated with renal lipomatosis, inflammation and oxidative stress. Vitamin E is a liposoluble antioxidant vitamin and PLGA (polylactic-CO-glycolic acid) nanoparticles (NPs) represent a delivery carrier of this vitamin to the abdominal viscera. The aim of this study is to evaluate the r...

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Veröffentlicht in:Revista de chimie (Bucuresti) 2020-07, Vol.71 (6), p.230-237
Hauptverfasser: Dinu, Adriana, Virgolici, Bogdana, Miricescu, Daniela, Totan, Alexandra, Gagniuc, Elvira, Virgolici, Horia, Stefan, Daciana Costina, Greabu, Maria, Mohora, Maria
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Sprache:eng
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Zusammenfassung:Obesity is associated with renal lipomatosis, inflammation and oxidative stress. Vitamin E is a liposoluble antioxidant vitamin and PLGA (polylactic-CO-glycolic acid) nanoparticles (NPs) represent a delivery carrier of this vitamin to the abdominal viscera. The aim of this study is to evaluate the renal and systemic effects of PLGA- NPs loaded with vitamin E in high fat diet Wistar rats. Young heathy Wistar male rats (3months old, n=20) were fed for 4 weeks either with standard diet or with high caloric/fat diet. These two experimental groups were divided in two subgroups and for the following 21 days, one group received PLGA-NPs loaded with vitamin E (1 mg/kg) body and the other didn t. Metabolic serum parameters, oxidative stress markers ( malondialdehyde, MDA and total thiols) from kidney homogenates were measured by spectrophotometric methods. Hematoxylin-eosin stain histopathologic examination of kidneys was performed. The obesogenic diet increased the serum levels for triglycerides (p[0.001) and renal function markers: urea (p[0.02), creatinine (p[0.02) and cystatin (p[0.01). The treatment reduced the kidney inflammation, prevented tubulonephrosis damage and improved the renal oxidative stress markers (p[0.05) in the high fat diet group. In conclusion, PLGA-NPs loaded with vitamin E had renoprotective effect in high fat diet Wistar rats.
ISSN:0034-7752
2668-8212
DOI:10.37358/RC.20.6.8187