Immune Inflammation Related to Obesity in Pregnant Women

Although there are many conditions to be met for the disease to occur (genetic predisposition, environmental factors, stress, exposure to pollutants, noxes, xenobiotics, diet), chronic inflammation is the way how the body responds to these substances. Excess weight leads to an alteration of the immune response, to an increased oxidative stress, and damage to the cellular Deoxyribonucleic acid (DNA) structure. The study aims to evaluate inflammation in obese mothers. The study group consisted of 30 pregnant women in which inflammation was analysed, with a mean age of 30.80 6,94 years old divided in 2 groups depending on their weight, that is 25 pregnant women with obesity and 5 normoponderal pregnant women. From the markers found in the blood samples, only CRP (AUC=0.740; IC95%: 0.466-1.014), leptin (AUC=0.616; IC95%: 0.296-0.936) and glycaemia (AUC=0.648; IC95%: 0.369-0.927) were good indicators of immune inflammation. The estimated risk of immune inflammation is 5 times higher in obese pregnancies with CRP levels above 6.