Involvement of Adiponectin in Early Phase of Acute Myocardial Infarction with ST-Segment Elevation (STEMI)

Adiponectin is secreted by fatty tissue; it has a peptide biochemical structure and among other roles, it seems to inhibit endothelial inflammation. C-reactive protein has an essential role in host defense. Troponin is a protein that is part of cardiac and skeletal muscle contraction. Myocardial infarction is an acute event defined as myocardial cell necrosis, caused by sudden and sustained ischemia. The purpose of our search work was to analyze the connection between various biomarkers over the early phase of acute STEMI: adiponectin, high sensitive-C reactive protein (hs-CRP), high sensitive-Troponin T (hs-Troponin T), triglycerides, total -, LDL- and HDL-cholesterol. Our study included two groups of patients - one group of 30 patients diagnosed with STEMI in the first 12 h after onset, and the second group of 30 patients with unstable angina pectoris, normal hs-Troponin T, and normal findings at coronary angiography computed tomography (CT). Subjects in the STEMI-arm had a higher serum level of hs-CRP, hs-Troponin T, total cholesterol, LDL cholesterol, triglycerides, and decreased levels of HDL-cholesterol and adiponectin than those in the angina-arm. We identified diminished adiponectin plasma concentrations during the first hours of STEMI evolution. We also found out a directly proportional ratio among adiponectin and HDL-cholesterol and an inverse report between this hormone and all other studied biomarkers. Our results may support the anti-inflammatory and anti-atherogenic features of adiponectin.