Adiponectin mRNA and Metabolic Profile in Malignant Obesesity

The aim of our study was to assess mRNA levels in visceral fat tissue and to correlate them with clinical-biological parameters in morbidly obese patients. 38 morbidly obese patients were selected and 8 cases of non obese subjects. The expression levels of adiponectin mRNA were determined through RT-PCR. Also we assessed biochemical parameters like seric glucose level, total cholesterol and triglicerides. The expression levels of adiponectin mRNA were correlated with demographic parameters (age, sex, BMI) and with clinical parameters (HTA, hypothyroidism and type 2 diabetes). This study showed significant correlations between adiponectin mRNA levels with obesity, age, triglicerids, total cholesterol and hypothyroidism. In conclusion, the expression level of adiponectin could be used as a molecular marker in the management of obesity.