Synthesis and Characterization of New Heterocyclic Condensed Systems with Bridgehead Nitrogen from Thiazolo[3,2-b][1,2,4]triazol-6(5H)-ones Class with Potential Antimicrobial Activity

In this study, the synthesis and characterization of new thiazolo[3,2-b][1,2,4]triazol-6(5H)-ones 3-5 are described starting from 5-[4-(4-X-phenylsulfonyl)phenyl]-4H-1,2,4-triazole-3-thioles 2. The treatment of 1,2,4-triazole-3-thioles 2 with chloroacetic acid and substituted or non-substituted benzaldehydes in the presence of sodium acetate, acetic acid and acetic anhydride gave fused ring compounds 3-5. The structures of thiazolo-triazolones 3-5 have been elucidate by elemental analysis and IR, UV, 1H-NMR, 13C-NMR, MS spectra. Some of the newly synthesized products were tested for their antimicrobial effects.