PLGA - gallic Acid Advanced Drug Delivery System as New Functional Material

PLGA - gallic Acid Advanced Drug Delivery System as New Functional Material

Combining polimers with polyphenols such as gallic acid opens up new directions in healthcare system. By encapsulating secondary metabollites within PLGA nanoparticles, we tried to enhance their stability, solubility, and obtain a targeted delivery system. In this study, we synthesized a PLGA-gallic...

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Veröffentlicht in:Materiale Plastice 2024-01, Vol.60 (4), p.79-86
Hauptverfasser: Poenariu, Anne-Marie Beatrice, Postelnicu, Roberto Angelo, Ciocilteu, Maria Viorica, Rau, Gabriela, Popescu, Mariana, Simionescu, Andreea, Neacsu, Ionela Andreea, Nicolicescu, Claudiu, Amzoiu, Denisa Constantina
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Sprache:eng
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Zusammenfassung:Combining polimers with polyphenols such as gallic acid opens up new directions in healthcare system. By encapsulating secondary metabollites within PLGA nanoparticles, we tried to enhance their stability, solubility, and obtain a targeted delivery system. In this study, we synthesized a PLGA-gallic acid sustained release system, using the solvent evaporation method. This approach improved the therapeutic efficacy of gallic acid. The numerical distribution showed that most PLGA-GA nanoparticles have a size of 10 nm. Through the method of solvent evaporation, an incorporation efficiency of 49% was obtained.
ISSN:0025-5289
2668-8220
DOI:10.37358/MP.23.4.5688