Human Leukocyte Antigen-DP in Acute Nonlymphocytic and Acute Lymphoblastic Leukemia

Acute leukemias are characterized by the elonogenic proliferation   of haemopoietic progenitor cells arrested in maturation. Clinical manifestations are related to the infiltration of the bone marrow and other tissues by the leukemic blasts.   Peripheral blood mononuclear cell (PBMC) from luekemic p...

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Veröffentlicht in:Journal of the College of Basic Education 2023-01 (50), p.43-50
1. Verfasser: Majid Sakhi Jabir
Format: Artikel
Sprache:eng
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Zusammenfassung:Acute leukemias are characterized by the elonogenic proliferation   of haemopoietic progenitor cells arrested in maturation. Clinical manifestations are related to the infiltration of the bone marrow and other tissues by the leukemic blasts.   Peripheral blood mononuclear cell (PBMC) from luekemic patients (29)ANLL,(36)ALL and from normal donors(55)were typed for HLA- DP specificities using microlymphocytotoxicity assay.   Results showed frequencies of DPw alleles in ANLL patients were not significantly different from controls ,exept that in DPw1 was absent .In contrast ,in ALL,frequencies of DPw2 and DPw5 were significantly increased (p
ISSN:1815-7467
2706-8536
DOI:10.35950/cbej.vi50.9821