Analytical Method Development & Validation Protocol For Trospium Chloride In Tablet Dosage Form
Trospium Chloride is an antispasmodic, antimuscarinic agent. It is used in the treatment of overactive bladder with urge incontinence. It is also used as anticholinergic compound. It acts as a direct antagonist at muscarinic acetylcholine receptors in cholinergically innervated organs. It appears as...
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| Veröffentlicht in: | Indo global journal of pharmaceutical sciences 2011, Vol.1 (2), p.166-172 |
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| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Trospium Chloride is an antispasmodic, antimuscarinic agent. It is used in the treatment of overactive bladder with urge incontinence. It is also used as anticholinergic compound. It acts as a direct antagonist at muscarinic acetylcholine receptors in cholinergically innervated organs. It appears as white crystalline powder. It is very soluble in water, freely soluble in methanol and practically insoluble in methylene chloride. A simple spectrophotometric method was developed for the determination of Trospium Chloride in pharmaceutical tablet dosage form. Trospium Chloride exhibiting λ max at 224 nm in mobile phase (0.1 N HCl ) and obeyed linearity in the concentration range of 10 – 60 mcg. The proposed method was statistically validated. © 2011 IGJPS. All rights reserved |
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| ISSN: | 2249-1023 2249-1023 |
| DOI: | 10.35652/IGJPS.2011.17 |