Histomorphological and histomorphometric analysis of wollastonite and tricalcium phosphate composite at different concentrations after in vivo implantation

Purpose: To evaluate, through histomorphometric analysis in critical bone defect, the osteogenic behavior of new glass-ceramic biomaterials in granules, named different from pseudowollastonite (p-W) and beta tricalcium phosphate (β-TCP). Methods: Forty Wistar rats were randomly distributed into 4 groups, with 5 animals in each group recovered at 15 and 45 days: G20/80 (20% p-wollastonite and 80% β-tricalcium phosphate); G60/40 (60% p-W and 40% β-TCP); G80/20 (80% p-W and 20% β-TCP); and CG (control group). Results: A histomorphological analysis showed that, in all rules, the composites were biocompatible and bioactive. The G60/40 presents osteoid matrix deposition in 65% of the bone defect at 45 days. While the other groups formed similar percentages of bone neoformation in both biological points. Conclusion: The studied composites are biocompatible, fillers and osteoconductive.