Xanthine Oxidase Inhibition and Anti-LDL Oxidation by Prenylated Isoflavones from Flemingia philippinensis Root

Xanthine oxidase is a frontier enzyme to produce oxidants, which leads to inflammation in the blood. Prenylated isoflavones from Flemingia philippinens is were found to display potent inhibition against xanthine oxidase (XO). All isolates (1-9) inhibited XO enzyme with IC50 ranging 7.8 similar to 36...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2020-07, Vol.25 (13), p.3074, Article 3074
Hauptverfasser:	Kim, Jeong Yoon, Wang, Yan, Li, Zuo Peng, Baiseitova, Aizhamal, Ban, Yeong Jun, Park, Ki Hun
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-LDL oxidation Antioxidants Atherosclerosis Biochemistry & Molecular Biology Bone density Catechol Chemistry Chemistry, Multidisciplinary Chromatography, Liquid Copper - chemistry Copper compounds Electrophoretic mobility Enzyme Inhibitors - chemistry Enzymes Fabaceae - chemistry Flemingia philippinensis Fluorescence Genistein Inhibitory Concentration 50 Isoflavones Isoflavones - analysis Isoflavones - chemistry Isoflavones - isolation & purification Isoflavones - pharmacology Kinetics Lag time Legumes Life Sciences & Biomedicine Lipoproteins, LDL - metabolism Low density lipoprotein Mass Spectrometry Metabolites Oxidants Oxidation Oxidation effects Oxidation-Reduction Oxidative stress Oxidizing agents Physical Sciences Plant Extracts - chemistry Plant Extracts - pharmacology Plant Roots - chemistry prenylated isoflavones Prenylation Science & Technology Thiobarbiturates - chemistry Thiobarbituric acid Uric acid Xanthine oxidase Xanthine Oxidase - antagonists & inhibitors Xanthine Oxidase - metabolism xanthine oxidase inhibition
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Zusammenfassung:	Xanthine oxidase is a frontier enzyme to produce oxidants, which leads to inflammation in the blood. Prenylated isoflavones from Flemingia philippinens is were found to display potent inhibition against xanthine oxidase (XO). All isolates (1-9) inhibited XO enzyme with IC50 ranging 7.8 similar to 36.4 mu M. The most active isoflavones (2-5, IC50= 7.8 similar to 14.8 mu M) have the structural feature of a catechol motif in B-ring. Inhibitory behaviors were disclosed as a mixed type I mode of inhibition with K-I
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules25133074