Fetal Hemoglobin as a Predictive Biomarker for Retinopathy of Prematurity: A Prospective Multicenter Cohort Study in Portugal

Retinopathy of prematurity (ROP) is a leading cause of vision impairment in preterm infants, with its pathogenesis linked to oxygen exposure. Red blood cell (RBC) transfusions, commonly performed in neonatal intensive care units (NICUs), reduce fetal hemoglobin (HbF) fraction, altering oxygen dynami...

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Veröffentlicht in:	Biomedicines 2025-01, Vol.13 (1), p.110
Hauptverfasser:	Fevereiro-Martins, Mariza, Aguiar, Laura, Inácio, Ângela, Cardoso, Carlos, Santos, Ana Carolina, Marques-Neves, Carlos, Guimarães, Hercília, Pinto, Rui, Bicho, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Birth weight Capillary electrophoresis Congenital diseases Disease prevention Erythrocytes fetal hemoglobin Fetuses Gestational age Hemoglobin Hypoxia Infants innovative therapeutic approaches Intensive care units neonatal anemia Neonatal care neonatal diseases Neonates Newborn babies Pathogenesis pathophysiology Premature babies Retina Retinal detachment Retinopathy retinopathy of prematurity Statistical analysis Vascular endothelial growth factor
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Zusammenfassung:	Retinopathy of prematurity (ROP) is a leading cause of vision impairment in preterm infants, with its pathogenesis linked to oxygen exposure. Red blood cell (RBC) transfusions, commonly performed in neonatal intensive care units (NICUs), reduce fetal hemoglobin (HbF) fraction, altering oxygen dynamics and potentially contributing to ROP. We aimed to investigate the relationship between RBC transfusions, HbF percentage, and ROP, evaluating HbF as a potential predictive biomarker. A multicenter, prospective study was conducted across eight Portuguese NICUs, involving infants born at
ISSN:	2227-9059 2227-9059
DOI:	10.3390/biomedicines13010110