Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD
BackgroundPrevious studies on the association between thyroid function and non-alcoholic fatty liver disease (NAFLD) have contradicted. Acquired resistance to thyroid hormone theory might provide a reasonable explanation for these contradictions. We aimed to analyze the association between sensitivi...
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| description | BackgroundPrevious studies on the association between thyroid function and non-alcoholic fatty liver disease (NAFLD) have contradicted. Acquired resistance to thyroid hormone theory might provide a reasonable explanation for these contradictions. We aimed to analyze the association between sensitivity to thyroid hormone indices with NAFLD. MethodsA total of 4,610 individuals from the health medical center of the First Hospital of China Medical University were included in this study. The previously used thyroid feedback quantile-based index (TFQI(FT4)) was calculated. Also, we substituted free triiodothyronine (FT3) into the TFQI formulas to get the TFQI(FT3) index. NAFLD was defined using abdominal ultrasound. ResultsStudy results showed that FT3/FT4 and TFQI(FT3) were positively correlated with the triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels (P |
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Acquired resistance to thyroid hormone theory might provide a reasonable explanation for these contradictions. We aimed to analyze the association between sensitivity to thyroid hormone indices with NAFLD. MethodsA total of 4,610 individuals from the health medical center of the First Hospital of China Medical University were included in this study. The previously used thyroid feedback quantile-based index (TFQI(FT4)) was calculated. Also, we substituted free triiodothyronine (FT3) into the TFQI formulas to get the TFQI(FT3) index. NAFLD was defined using abdominal ultrasound. ResultsStudy results showed that FT3/FT4 and TFQI(FT3) were positively correlated with the triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels (P<0.05) and negatively correlated with high-density lipoprotein cholesterol (HDL-C) level (P<0.05). In contrast, TFQI(FT4) was positively correlated with HDL-C level (P < 0.05). After adjustment for multiple confounders, FT3, FT3/FT4, and TFQI(FT3) were positively associated with the risks of dyslipidemia and NAFLD (P < 0.05). TFQI(FT3) and FT3/FT4 performed better than TFQI(FT4) on ROC analyses for NAFLD prediction, although the diagnostic sensitivity and specificity at the optimal cut-points were low. However, no association was observed between TFQI(FT4) with the risks of dyslipidemia and NAFLD. ConclusionTFQI(FT3) and FT3/FT4 can be used as new indicators for predicting dyslipidemia and NAFLD, although with low sensitivity and specificity at the optimal cut-points, while TFQI(FT4) has insufficient evidence in predicting dyslipidemia and NAFLD.</description><identifier>ISSN: 1664-2392</identifier><identifier>EISSN: 1664-2392</identifier><identifier>DOI: 10.3389/fendo.2021.766419</identifier><identifier>PMID: 34803928</identifier><language>eng</language><publisher>LAUSANNE: Frontiers Media Sa</publisher><subject>China ; Cholesterol, LDL - blood ; dyslipidemia ; Dyslipidemias - blood ; Endocrinology ; Endocrinology & Metabolism ; Female ; Humans ; Life Sciences & Biomedicine ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease - blood ; Non-alcoholic Fatty Liver Disease - etiology ; non‐alcoholic fatty liver disease ; Risk Factors ; Science & Technology ; Sensitivity and Specificity ; sensitivity to thyroid hormone indices ; thyroid feedback quantile-based index ; thyroid function ; Thyroid Function Tests - methods ; Thyroid Gland - metabolism ; Thyroid Hormones - blood ; Thyrotropin - blood ; Thyroxine - blood ; Triglycerides - blood ; Triiodothyronine - blood ; Ultrasonography - methods</subject><ispartof>Frontiers in endocrinology (Lausanne), 2021-11, Vol.12, p.766419-766419, Article 766419</ispartof><rights>Copyright © 2021 Lai, Li, Wang, Wang and Guan.</rights><rights>Copyright © 2021 Lai, Li, Wang, Wang and Guan 2021 Lai, Li, Wang, Wang and Guan</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>34</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000720438000001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c465t-a488cb6a5dba78ed4af8abdeb046489c86165e2230d13c9c8a18cefdf049583a3</citedby><cites>FETCH-LOGICAL-c465t-a488cb6a5dba78ed4af8abdeb046489c86165e2230d13c9c8a18cefdf049583a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602917/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602917/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27929,27930,39263,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34803928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lai, Shuiqing</creatorcontrib><creatorcontrib>Li, Jiarong</creatorcontrib><creatorcontrib>Wang, Zixiao</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Guan, Haixia</creatorcontrib><title>Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD</title><title>Frontiers in endocrinology (Lausanne)</title><addtitle>FRONT ENDOCRINOL</addtitle><addtitle>Front Endocrinol (Lausanne)</addtitle><description>BackgroundPrevious studies on the association between thyroid function and non-alcoholic fatty liver disease (NAFLD) have contradicted. Acquired resistance to thyroid hormone theory might provide a reasonable explanation for these contradictions. We aimed to analyze the association between sensitivity to thyroid hormone indices with NAFLD. MethodsA total of 4,610 individuals from the health medical center of the First Hospital of China Medical University were included in this study. The previously used thyroid feedback quantile-based index (TFQI(FT4)) was calculated. Also, we substituted free triiodothyronine (FT3) into the TFQI formulas to get the TFQI(FT3) index. NAFLD was defined using abdominal ultrasound. ResultsStudy results showed that FT3/FT4 and TFQI(FT3) were positively correlated with the triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels (P<0.05) and negatively correlated with high-density lipoprotein cholesterol (HDL-C) level (P<0.05). In contrast, TFQI(FT4) was positively correlated with HDL-C level (P < 0.05). After adjustment for multiple confounders, FT3, FT3/FT4, and TFQI(FT3) were positively associated with the risks of dyslipidemia and NAFLD (P < 0.05). TFQI(FT3) and FT3/FT4 performed better than TFQI(FT4) on ROC analyses for NAFLD prediction, although the diagnostic sensitivity and specificity at the optimal cut-points were low. However, no association was observed between TFQI(FT4) with the risks of dyslipidemia and NAFLD. ConclusionTFQI(FT3) and FT3/FT4 can be used as new indicators for predicting dyslipidemia and NAFLD, although with low sensitivity and specificity at the optimal cut-points, while TFQI(FT4) has insufficient evidence in predicting dyslipidemia and NAFLD.</description><subject>China</subject><subject>Cholesterol, LDL - blood</subject><subject>dyslipidemia</subject><subject>Dyslipidemias - blood</subject><subject>Endocrinology</subject><subject>Endocrinology & Metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Non-alcoholic Fatty Liver Disease - blood</subject><subject>Non-alcoholic Fatty Liver Disease - etiology</subject><subject>non‐alcoholic fatty liver disease</subject><subject>Risk Factors</subject><subject>Science & Technology</subject><subject>Sensitivity and Specificity</subject><subject>sensitivity to thyroid hormone indices</subject><subject>thyroid feedback quantile-based index</subject><subject>thyroid function</subject><subject>Thyroid Function Tests - methods</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid Hormones - blood</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Triglycerides - blood</subject><subject>Triiodothyronine - blood</subject><subject>Ultrasonography - methods</subject><issn>1664-2392</issn><issn>1664-2392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqNkUtrGzEURoeS0oQ0P6CbMstCsKvXaKRNwUya2mDaRVO6FBrpTqwwllJJTvC_r5xJTbKrNnrc7x5dOFX1AaM5pUJ-HsDbMCeI4HnLOcPyTXWGy2FGqCQnL86n1UVKd6gshrCU4l11SplApSLOquVP8Mll9-Dyvs6hvtnsY3C2Xoa4DR7qlbfOQKoXEepuDAnGfb1IKRinM9j6t8ub-vvien31vno76DHBxfN-Xv26_nrTLWfrH99W3WI9M4w3eaaZEKbnurG9bgVYpgehews9YpwJaQTHvAFCKLKYmnLXWBgY7ICYbATV9LxaTVwb9J26j26r414F7dTTQ4i3SsfszAiqsYYbzAlj2jDdSGlkb4URFOmhEZIW1peJdb_rt2AN-Bz1-Ar6uuLdRt2GByU4IhK3BfDpGRDDnx2krLYuGRhH7SHskiIcIUEoaXGJ4ilqYkgpwnD8BiN1EKqehKqDUDUJLT0fX8537PinrwQup8Aj9GFIxoE3cIwV4y1BjIqDe3QYQfx_unNZZxd8F3Y-078pDL3s</recordid><startdate>20211105</startdate><enddate>20211105</enddate><creator>Lai, Shuiqing</creator><creator>Li, Jiarong</creator><creator>Wang, Zixiao</creator><creator>Wang, Wei</creator><creator>Guan, Haixia</creator><general>Frontiers Media Sa</general><general>Frontiers Media S.A</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20211105</creationdate><title>Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD</title><author>Lai, Shuiqing ; Li, Jiarong ; Wang, Zixiao ; Wang, Wei ; Guan, Haixia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-a488cb6a5dba78ed4af8abdeb046489c86165e2230d13c9c8a18cefdf049583a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>China</topic><topic>Cholesterol, LDL - blood</topic><topic>dyslipidemia</topic><topic>Dyslipidemias - blood</topic><topic>Endocrinology</topic><topic>Endocrinology & Metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Non-alcoholic Fatty Liver Disease - blood</topic><topic>Non-alcoholic Fatty Liver Disease - etiology</topic><topic>non‐alcoholic fatty liver disease</topic><topic>Risk Factors</topic><topic>Science & Technology</topic><topic>Sensitivity and Specificity</topic><topic>sensitivity to thyroid hormone indices</topic><topic>thyroid feedback quantile-based index</topic><topic>thyroid function</topic><topic>Thyroid Function Tests - methods</topic><topic>Thyroid Gland - metabolism</topic><topic>Thyroid Hormones - blood</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Triglycerides - blood</topic><topic>Triiodothyronine - blood</topic><topic>Ultrasonography - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lai, Shuiqing</creatorcontrib><creatorcontrib>Li, Jiarong</creatorcontrib><creatorcontrib>Wang, Zixiao</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Guan, Haixia</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in endocrinology (Lausanne)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lai, Shuiqing</au><au>Li, Jiarong</au><au>Wang, Zixiao</au><au>Wang, Wei</au><au>Guan, Haixia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD</atitle><jtitle>Frontiers in endocrinology (Lausanne)</jtitle><stitle>FRONT ENDOCRINOL</stitle><addtitle>Front Endocrinol (Lausanne)</addtitle><date>2021-11-05</date><risdate>2021</risdate><volume>12</volume><spage>766419</spage><epage>766419</epage><pages>766419-766419</pages><artnum>766419</artnum><issn>1664-2392</issn><eissn>1664-2392</eissn><abstract>BackgroundPrevious studies on the association between thyroid function and non-alcoholic fatty liver disease (NAFLD) have contradicted. Acquired resistance to thyroid hormone theory might provide a reasonable explanation for these contradictions. We aimed to analyze the association between sensitivity to thyroid hormone indices with NAFLD. MethodsA total of 4,610 individuals from the health medical center of the First Hospital of China Medical University were included in this study. The previously used thyroid feedback quantile-based index (TFQI(FT4)) was calculated. Also, we substituted free triiodothyronine (FT3) into the TFQI formulas to get the TFQI(FT3) index. NAFLD was defined using abdominal ultrasound. ResultsStudy results showed that FT3/FT4 and TFQI(FT3) were positively correlated with the triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels (P<0.05) and negatively correlated with high-density lipoprotein cholesterol (HDL-C) level (P<0.05). In contrast, TFQI(FT4) was positively correlated with HDL-C level (P < 0.05). After adjustment for multiple confounders, FT3, FT3/FT4, and TFQI(FT3) were positively associated with the risks of dyslipidemia and NAFLD (P < 0.05). TFQI(FT3) and FT3/FT4 performed better than TFQI(FT4) on ROC analyses for NAFLD prediction, although the diagnostic sensitivity and specificity at the optimal cut-points were low. However, no association was observed between TFQI(FT4) with the risks of dyslipidemia and NAFLD. ConclusionTFQI(FT3) and FT3/FT4 can be used as new indicators for predicting dyslipidemia and NAFLD, although with low sensitivity and specificity at the optimal cut-points, while TFQI(FT4) has insufficient evidence in predicting dyslipidemia and NAFLD.</abstract><cop>LAUSANNE</cop><pub>Frontiers Media Sa</pub><pmid>34803928</pmid><doi>10.3389/fendo.2021.766419</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | China Cholesterol, LDL - blood dyslipidemia Dyslipidemias - blood Endocrinology Endocrinology & Metabolism Female Humans Life Sciences & Biomedicine Male Middle Aged Non-alcoholic Fatty Liver Disease - blood Non-alcoholic Fatty Liver Disease - etiology non‐alcoholic fatty liver disease Risk Factors Science & Technology Sensitivity and Specificity sensitivity to thyroid hormone indices thyroid feedback quantile-based index thyroid function Thyroid Function Tests - methods Thyroid Gland - metabolism Thyroid Hormones - blood Thyrotropin - blood Thyroxine - blood Triglycerides - blood Triiodothyronine - blood Ultrasonography - methods |
| title | Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD |
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