Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD

BackgroundPrevious studies on the association between thyroid function and non-alcoholic fatty liver disease (NAFLD) have contradicted. Acquired resistance to thyroid hormone theory might provide a reasonable explanation for these contradictions. We aimed to analyze the association between sensitivity to thyroid hormone indices with NAFLD. MethodsA total of 4,610 individuals from the health medical center of the First Hospital of China Medical University were included in this study. The previously used thyroid feedback quantile-based index (TFQI(FT4)) was calculated. Also, we substituted free triiodothyronine (FT3) into the TFQI formulas to get the TFQI(FT3) index. NAFLD was defined using abdominal ultrasound. ResultsStudy results showed that FT3/FT4 and TFQI(FT3) were positively correlated with the triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels (P