Novel Oxygen Fused Bicyclic Derivatives and Antioxidant Labelling: Bioactive Chalcone Based Green Synthesis

Chalcone has become a matter of focus because of its wide variety of biological actions, such as anti-inflammation, anti-cancer, anti-tuberculosis, etc. Due to its inherent chemical reactivity, chalcone has become an easily accessible building block to construct various naturally and biologically active compounds. In modern times, the title compound is made possible to prepare through Claisen-Schmidt reaction or Aldol reaction. However, it is carried out under a conventional condition with a considerable number of variables (time, temperature, reagents, instrument parameters, etc.). In the present research work, we report a novel series of chalcone-based heterocyclic moieties along with an eco-friendly condensation reaction method permitting a ‘green approach’ to the present work. Thin-layer chromatography (TLC) was used to monitor the ’reaction’s progress, and Rf values were recorded. All of the synthesized derivative’s FTIR spectra were reported. This research focuses on seeing if green approaches can be used to synthesize the target chemical. In comparison to previous procedures, these approaches were more convenient and generated a greater yield (75-80%), showed maximum efficiency, and were stored without polluting the environment while also providing medicinal benefits. This method provides a faster reaction time, is safer for analysts, is minimal in cost, and is simple to implement. Additionally, the antioxidant activity of synthesized ligands with the DPPH assay has been studied.