Ethanolic Extracts of the Gongronema latifolium Stem and Leaves Caused Mild Renal Injury and Modulated Serum Triglycerides in Rats
Gongronema latifolium is a tropical plant with verse traditionally and medicinal uses in mostly Africa and Asia. In this work, we determined the biochemical effects of G. latifolium ethanolic extracts in male Wistar rats. The G. latifolium stem and leaves were air-dried separately, macerated, and ex...
Gespeichert in:
| Veröffentlicht in: | Biointerface Research in Applied Chemistry 2022-08, Vol.12 (4), p.5045-5053 |
|---|---|
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 5053 |
|---|---|
| container_issue | 4 |
| container_start_page | 5045 |
| container_title | Biointerface Research in Applied Chemistry |
| container_volume | 12 |
| description | Gongronema latifolium is a tropical plant with verse traditionally and medicinal uses in mostly Africa and Asia. In this work, we determined the biochemical effects of G. latifolium ethanolic extracts in male Wistar rats. The G. latifolium stem and leaves were air-dried separately, macerated, and extracted in 80 % ethanol. The Wistar rats were assigned into three groups randomly; control was administered distilled water, the treatment groups respectively were given 200 mg/kg bw of the extracts of leaves or stem for twenty-eight (28) days. Data showed that the rat serum ALT and ALP activities were lower in the extract-treated group than in the control group administered distilled water. In the rat liver, there were significant differences (p |
| doi_str_mv | 10.33263/BRIAC124.50455053 |
| format | Article |
| fullrecord | <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_33263_BRIAC124_50455053</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_33263_BRIAC124_50455053</sourcerecordid><originalsourceid>FETCH-LOGICAL-c291t-7e3f5376b8b79914564ecd3ddc72060cd5810e3a4f24ed0aee949c7f21f1d4a93</originalsourceid><addsrcrecordid>eNpNkNtqAjEQhkNpoWJ9gV7lBdbmuIdLu1grKAW110tMJrqyh5JkS73tkzfYCp2bGZj_G5gPoUdKppyzlD89b5azkjIxlURISSS_QSNG0iKROc9u_833aOL9icSSGcs5HaHveTiqrm9qjedfwSkdPO4tDkfAi747uL6DVuFGhdrG0NDibYAWq87gFahP8LhUgweD13Vj8AY61eBldxrc-ZJZ92aIbNxvwUV45-pDc9bgahPRusMbFfwDurOq8TD562P0_jLfla_J6m2xLGerRLOChiQDbiXP0n2-z4qCCpkK0IYbo7P4H9FG5pQAV8IyAYYogEIUOrOMWmqEKvgYsd-72vXeO7DVh6tb5c4VJdVFZHUVWV1F8h8zEGgV</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Ethanolic Extracts of the Gongronema latifolium Stem and Leaves Caused Mild Renal Injury and Modulated Serum Triglycerides in Rats</title><source>EZB-FREE-00999 freely available EZB journals</source><description>Gongronema latifolium is a tropical plant with verse traditionally and medicinal uses in mostly Africa and Asia. In this work, we determined the biochemical effects of G. latifolium ethanolic extracts in male Wistar rats. The G. latifolium stem and leaves were air-dried separately, macerated, and extracted in 80 % ethanol. The Wistar rats were assigned into three groups randomly; control was administered distilled water, the treatment groups respectively were given 200 mg/kg bw of the extracts of leaves or stem for twenty-eight (28) days. Data showed that the rat serum ALT and ALP activities were lower in the extract-treated group than in the control group administered distilled water. In the rat liver, there were significant differences (p<0.05) in biochemical parameters compared to the control group as the extract-treated group showed a reduction in ALT, AST, and ALP activities. Meanwhile, the oral administration of the G. latifolium extracts led to the elevated (p<0.05) level of serum urea, while the serum triglycerides and creatinine levels were reduced compared with the control. Together, the data suggest that G. latifolium extracts at the doses tested had minimal renal toxicity.</description><identifier>ISSN: 2069-5837</identifier><identifier>EISSN: 2069-5837</identifier><identifier>DOI: 10.33263/BRIAC124.50455053</identifier><language>eng</language><ispartof>Biointerface Research in Applied Chemistry, 2022-08, Vol.12 (4), p.5045-5053</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c291t-7e3f5376b8b79914564ecd3ddc72060cd5810e3a4f24ed0aee949c7f21f1d4a93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><title>Ethanolic Extracts of the Gongronema latifolium Stem and Leaves Caused Mild Renal Injury and Modulated Serum Triglycerides in Rats</title><title>Biointerface Research in Applied Chemistry</title><description>Gongronema latifolium is a tropical plant with verse traditionally and medicinal uses in mostly Africa and Asia. In this work, we determined the biochemical effects of G. latifolium ethanolic extracts in male Wistar rats. The G. latifolium stem and leaves were air-dried separately, macerated, and extracted in 80 % ethanol. The Wistar rats were assigned into three groups randomly; control was administered distilled water, the treatment groups respectively were given 200 mg/kg bw of the extracts of leaves or stem for twenty-eight (28) days. Data showed that the rat serum ALT and ALP activities were lower in the extract-treated group than in the control group administered distilled water. In the rat liver, there were significant differences (p<0.05) in biochemical parameters compared to the control group as the extract-treated group showed a reduction in ALT, AST, and ALP activities. Meanwhile, the oral administration of the G. latifolium extracts led to the elevated (p<0.05) level of serum urea, while the serum triglycerides and creatinine levels were reduced compared with the control. Together, the data suggest that G. latifolium extracts at the doses tested had minimal renal toxicity.</description><issn>2069-5837</issn><issn>2069-5837</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpNkNtqAjEQhkNpoWJ9gV7lBdbmuIdLu1grKAW110tMJrqyh5JkS73tkzfYCp2bGZj_G5gPoUdKppyzlD89b5azkjIxlURISSS_QSNG0iKROc9u_833aOL9icSSGcs5HaHveTiqrm9qjedfwSkdPO4tDkfAi747uL6DVuFGhdrG0NDibYAWq87gFahP8LhUgweD13Vj8AY61eBldxrc-ZJZ92aIbNxvwUV45-pDc9bgahPRusMbFfwDurOq8TD562P0_jLfla_J6m2xLGerRLOChiQDbiXP0n2-z4qCCpkK0IYbo7P4H9FG5pQAV8IyAYYogEIUOrOMWmqEKvgYsd-72vXeO7DVh6tb5c4VJdVFZHUVWV1F8h8zEGgV</recordid><startdate>20220815</startdate><enddate>20220815</enddate><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20220815</creationdate><title>Ethanolic Extracts of the Gongronema latifolium Stem and Leaves Caused Mild Renal Injury and Modulated Serum Triglycerides in Rats</title></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c291t-7e3f5376b8b79914564ecd3ddc72060cd5810e3a4f24ed0aee949c7f21f1d4a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>online_resources</toplevel><collection>CrossRef</collection><jtitle>Biointerface Research in Applied Chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethanolic Extracts of the Gongronema latifolium Stem and Leaves Caused Mild Renal Injury and Modulated Serum Triglycerides in Rats</atitle><jtitle>Biointerface Research in Applied Chemistry</jtitle><date>2022-08-15</date><risdate>2022</risdate><volume>12</volume><issue>4</issue><spage>5045</spage><epage>5053</epage><pages>5045-5053</pages><issn>2069-5837</issn><eissn>2069-5837</eissn><abstract>Gongronema latifolium is a tropical plant with verse traditionally and medicinal uses in mostly Africa and Asia. In this work, we determined the biochemical effects of G. latifolium ethanolic extracts in male Wistar rats. The G. latifolium stem and leaves were air-dried separately, macerated, and extracted in 80 % ethanol. The Wistar rats were assigned into three groups randomly; control was administered distilled water, the treatment groups respectively were given 200 mg/kg bw of the extracts of leaves or stem for twenty-eight (28) days. Data showed that the rat serum ALT and ALP activities were lower in the extract-treated group than in the control group administered distilled water. In the rat liver, there were significant differences (p<0.05) in biochemical parameters compared to the control group as the extract-treated group showed a reduction in ALT, AST, and ALP activities. Meanwhile, the oral administration of the G. latifolium extracts led to the elevated (p<0.05) level of serum urea, while the serum triglycerides and creatinine levels were reduced compared with the control. Together, the data suggest that G. latifolium extracts at the doses tested had minimal renal toxicity.</abstract><doi>10.33263/BRIAC124.50455053</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2069-5837 |
| ispartof | Biointerface Research in Applied Chemistry, 2022-08, Vol.12 (4), p.5045-5053 |
| issn | 2069-5837 2069-5837 |
| language | eng |
| recordid | cdi_crossref_primary_10_33263_BRIAC124_50455053 |
| source | EZB-FREE-00999 freely available EZB journals |
| title | Ethanolic Extracts of the Gongronema latifolium Stem and Leaves Caused Mild Renal Injury and Modulated Serum Triglycerides in Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T14%3A04%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-crossref&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ethanolic%20Extracts%20of%20the%20Gongronema%20latifolium%20Stem%20and%20Leaves%20Caused%20Mild%20Renal%20Injury%20and%20Modulated%20Serum%20Triglycerides%20in%20Rats&rft.jtitle=Biointerface%20Research%20in%20Applied%20Chemistry&rft.date=2022-08-15&rft.volume=12&rft.issue=4&rft.spage=5045&rft.epage=5053&rft.pages=5045-5053&rft.issn=2069-5837&rft.eissn=2069-5837&rft_id=info:doi/10.33263/BRIAC124.50455053&rft_dat=%3Ccrossref%3E10_33263_BRIAC124_50455053%3C/crossref%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |