Hepatoprotective Effect of Corrigiola telephiifolia Pourr. Root Methanolic Extracts against CCl4-Induced Hepatic Damage in Mice

Liver disease is a dysfunction that affects all or part of the liver and can lead to death. While the use of medicinal and aromatic plants has been a source of bioactive substances with hepatoprotective properties. This study aims to evaluate the hepatoprotective effect of the methanolic extract of Corrigiola telephiifolia roots on hepatic damage induced by carbon tetrachloride (CCl4) in mice. Animals were treated daily with C. telephiifolia methanolic extract (CTME) at doses of 5 and 10 mg/kg b.w for 60 days. In addition, CCl4 was injected (1 mL/kg, i.p.) for its hepatotoxic effects. At the end of the experiment, the blood of all animals was collected to evaluate biochemical parameters and the liver for histopathological analysis. The administration of CTME showed significant hepatoprotective activity by improving the biochemical parameters and the histological appearance of hepatic cells induced by CCl4. Consequently, C. telephiifolia could be used in the prevention and/or treatment of liver intoxication.