New Microorganisms which Convert Compactin to Pravastatin

New Microorganisms which Convert Compactin to Pravastatin

Screening of known and unidentified actinomycetes revealed three strains which can hydroxylate compactin to pravastatin. They showed taxonomic properties which are consistent with those of Actinomadura sp., Streptomyces tanashiensis and Streptomyces anulatus. Actinomadura sp. strain 2966 effected a...

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Veröffentlicht in:Actinomycetologica 1997/06/25, Vol.11(1), pp.20-25
Hauptverfasser: Yashphe, Jacob, Davis, Joseph, Peng, Yulin, Bok, Song H., Demain, Arnold L.
Format: Artikel
Sprache:eng
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Zusammenfassung:Screening of known and unidentified actinomycetes revealed three strains which can hydroxylate compactin to pravastatin. They showed taxonomic properties which are consistent with those of Actinomadura sp., Streptomyces tanashiensis and Streptomyces anulatus. Actinomadura sp. strain 2966 effected a 60% bioconversion of added compactin.
ISSN:0914-5818
1881-6371
DOI:10.3209/saj.11_20