Synthesis, Crystal Structure and Antitumour Activity of 3-Amino-4-Morpholino-1H-Indazol-1-yl(3-Fluorophenyl)Methanone

3-Amino-4-morpholino-1H-indazol-1-yl(3-fluorophenyl)methanone was synthesised by condensation of 3-fluorobenzoic acid with 4-morpholino-1H-indazol-3-amine, which was prepared from 2,6-difluorobenzonitrile by amination with morpholine and then cyclisation with hydrazine hydrate. The molecular structu...

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Veröffentlicht in:Journal of chemical research 2018-11, Vol.42 (11), p.552-555
Hauptverfasser: Tang, Zhi-hua, Fu, Wei-Jun
Format: Artikel
Sprache:eng
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Zusammenfassung:3-Amino-4-morpholino-1H-indazol-1-yl(3-fluorophenyl)methanone was synthesised by condensation of 3-fluorobenzoic acid with 4-morpholino-1H-indazol-3-amine, which was prepared from 2,6-difluorobenzonitrile by amination with morpholine and then cyclisation with hydrazine hydrate. The molecular structure was tested by single crystal X-ray diffraction. Preliminary biological tests showed that the compound possesses distinct inhibition on the proliferation of A549, BGC-823 and HepG-2 cancer cell lines.
ISSN:1747-5198
2047-6507
DOI:10.3184/174751918X15402939385990