Metabolic Fate and Expectation of Health Benefits of [U-14C]-Sucrose Inhibited from Digestion Using Morus alba Leaf Extract

Morus alba leaf extract (MLE), a strong inhibitor of sucrase, suppresses blood glucose elevation following sucrose ingestion. To investigate that sucrose inhibited from digestion using MLE is utilized through gut microbiota, [U-14C]-sucrose solutions with or without MLE were administered orally to c...

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Veröffentlicht in:Journal of Nutritional Science and Vitaminology 2022/08/31, Vol.68(4), pp.294-302
Hauptverfasser: OKU, Tsuneyuki, NAKAMURA, Sadako, TAKESHITA, Tomoya, HASHIGUCHI, Michiru, TANABE, Kenichi
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Sprache:eng
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Zusammenfassung:Morus alba leaf extract (MLE), a strong inhibitor of sucrase, suppresses blood glucose elevation following sucrose ingestion. To investigate that sucrose inhibited from digestion using MLE is utilized through gut microbiota, [U-14C]-sucrose solutions with or without MLE were administered orally to conventional and antibiotic-treated rats, and the excretion of 14CO2 and H2 produced by gut microbiota was measured for 24 h. After an administration of [U-14C]-sucrose to conventional rats, the unit excreted 14CO2 peaked at 4 h, and the cumulative 14CO2 excreted over 24 h was approximately 60% of the radioactivity administered. No H2 was excreted. Following an administration of [U-14C]-sucrose and MLE in conventional rats, the unit excreted 14CO2 peaked later, at 8 h, and was significantly lower (p
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.68.294