Trehalose Prevents Adipocyte Hypertrophy and Mitigates Insulin Resistance in Mice with Established Obesity

Our group recently demonstrated that simultaneous administration of trehalose with a high-fat diet (HFD) suppresses adipocyte hypertrophy and mitigates insulin resistance in mice. For the present study, we hypothesized that similar effects of trehalose would be observed in mice with previously-estab...

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Veröffentlicht in:	Journal of Nutritional Science and Vitaminology 2013, Vol.59(5), pp.393-401
Hauptverfasser:	ARAI, Chikako, MIYAKE, Masaki, MATSUMOTO, Yohsuke, MIZOTE, Akiko, YOSHIZANE, Chiyo, HANAYA, Yohko, KOIDE, Kazuhiro, YAMADA, Mika, HANAYA, Toshiharu, ARAI, Shigeyuki, FUKUDA, Shigeharu
Format:	Artikel
Sprache:	eng
Schlagworte:	adipocyte hypertrophy Adiponectin - agonists Adiponectin - blood Adiponectin - metabolism Adiposity Animals Diet, High-Fat - adverse effects Dietary Supplements Female Gene Expression Regulation Hyperinsulinism - diet therapy Hyperinsulinism - etiology Hyperinsulinism - pathology Hyperinsulinism - physiopathology Hypertrophy Insulin Receptor Substrate Proteins - agonists Insulin Receptor Substrate Proteins - genetics Insulin Receptor Substrate Proteins - metabolism Insulin Resistance Intra-Abdominal Fat - metabolism Intra-Abdominal Fat - pathology Metabolic Syndrome - etiology Metabolic Syndrome - prevention & control Mice Mice, Inbred C57BL Muscle, Skeletal - metabolism obese Obesity - etiology Obesity - physiopathology Random Allocation trehalose Trehalose - administration & dosage Trehalose - therapeutic use
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