Trehalose Prevents Adipocyte Hypertrophy and Mitigates Insulin Resistance in Mice with Established Obesity

Our group recently demonstrated that simultaneous administration of trehalose with a high-fat diet (HFD) suppresses adipocyte hypertrophy and mitigates insulin resistance in mice. For the present study, we hypothesized that similar effects of trehalose would be observed in mice with previously-estab...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of Nutritional Science and Vitaminology 2013, Vol.59(5), pp.393-401
Hauptverfasser:	ARAI, Chikako, MIYAKE, Masaki, MATSUMOTO, Yohsuke, MIZOTE, Akiko, YOSHIZANE, Chiyo, HANAYA, Yohko, KOIDE, Kazuhiro, YAMADA, Mika, HANAYA, Toshiharu, ARAI, Shigeyuki, FUKUDA, Shigeharu
Format:	Artikel
Sprache:	eng
Schlagworte:	adipocyte hypertrophy Adiponectin - agonists Adiponectin - blood Adiponectin - metabolism Adiposity Animals Diet, High-Fat - adverse effects Dietary Supplements Female Gene Expression Regulation Hyperinsulinism - diet therapy Hyperinsulinism - etiology Hyperinsulinism - pathology Hyperinsulinism - physiopathology Hypertrophy Insulin Receptor Substrate Proteins - agonists Insulin Receptor Substrate Proteins - genetics Insulin Receptor Substrate Proteins - metabolism Insulin Resistance Intra-Abdominal Fat - metabolism Intra-Abdominal Fat - pathology Metabolic Syndrome - etiology Metabolic Syndrome - prevention & control Mice Mice, Inbred C57BL Muscle, Skeletal - metabolism obese Obesity - etiology Obesity - physiopathology Random Allocation trehalose Trehalose - administration & dosage Trehalose - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Our group recently demonstrated that simultaneous administration of trehalose with a high-fat diet (HFD) suppresses adipocyte hypertrophy and mitigates insulin resistance in mice. For the present study, we hypothesized that similar effects of trehalose would be observed in mice with previously-established obesity. Obese mice were fed a HFD and drinking water containing 0.3 or 2.5% (weight/volume) trehalose or distilled water (DW) ad libitum for 8 wk. After 7 wk intake of a HFD and trehalose, fasting serum insulin levels and homeostasis model assessment-insulin resistance (HOMA-IR) in the 0.3% Tre/HFD group were significantly lower than those in the DW/HFD group (p
ISSN:	0301-4800 1881-7742
DOI:	10.3177/jnsv.59.393