A Dried Tofu-Supplemented Diet Affects mRNA Expression of Inflammatory Cytokines in Human Blood

In order to develop a new model of diet research, blood was drawn from 12 adult volunteers for 3 wk on regular diets as controls, and for a subsequent 3 wk supplemented with 18.5 g of freeze-dried tofu (Koya tofu) every day. Triplicate aliquots of 0.06 mL each of whole blood were stimulated ex vivo...

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Veröffentlicht in:Journal of Nutritional Science and Vitaminology 2010, Vol.56(6), pp.396-410
Hauptverfasser: TOVAR, Vivian, OGURA, Mieko, KOBAYASHI, Ai, KIMURA, Sayaka, SAITO, Kazunori, KAINUMA, Michiko, YOHDA, Masafumi, HASEGAWA, Setsuo, MITSUHASHI, Masato
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Sprache:eng
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Zusammenfassung:In order to develop a new model of diet research, blood was drawn from 12 adult volunteers for 3 wk on regular diets as controls, and for a subsequent 3 wk supplemented with 18.5 g of freeze-dried tofu (Koya tofu) every day. Triplicate aliquots of 0.06 mL each of whole blood were stimulated ex vivo with phytohemagglutinin (PHA)-P, heat aggregated human IgG (HAG), lipopolysaccharide (LPS), zymosan A, and anti-T cell receptor (TCR) monoclonal antibody to activate specific subsets of leukocytes, then the levels of various inflammatory cytokine mRNA were quantified by real time PCR. Koya tofu significantly (p
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.56.396