A Clinical Evaluation of Citicoline on Motor Paralyses in Cerebral Apoplectic Patients

1) The clinical effects of citicoline on apoplectic patients with long standing, fixed symptoms were evaluated by means of double-blind, cross-over methods and the difference in effects between citicoline and placebo were statistically examined by technique of sequential analysis. 2) The determination of orders of administration and selection of 10 out of 40 subjects were according to the randomized number table, while both orders of administration were planned to be equalized. 3) Activity of daily living (ADL), general improvement rating (GIR) and global comparative judgement (GCJ) were employed as criteria for the evaluation of symptoms and assesment of preferences. 4) The effect of citicoline on motor paralyses, especially rigidity of muscles and contracture of joints, was significantly better than that of placebo by assesment of either ADL, GIR or GCJ. 5) Neither abnormalities in laboratory tests nor subjective side effects were observed. 6) From these results, citicoline was evaluated to be significantly effective against motor paralyses, one of the main symptoms of post cerebral apoplexy.