Clinical efficacy of abatacept in Japanese rheumatoid arthritis patients

Clinical efficacy of abatacept in Japanese rheumatoid arthritis patients

Abstract Objectives The purpose of this study was to examine the treatment retention and efficacy of abatacept, the first member of a new class of biologic agents, in Japanese rheumatoid arthritis (RA) patients during clinical practice. Methods A retrospective multicenter study was conducted with pa...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Modern rheumatology 2013-09, Vol.23 (5), p.904-912
Hauptverfasser: Takahashi, Nobunori, Kojima, Toshihisa, Terabe, Kenya, Kaneko, Atsushi, Kida, Daihei, Hirano, Yuji, Fujibayashi, Takayoshi, Yabe, Yuichiro, Takagi, Hideki, Oguchi, Takeshi, Miyake, Hiroyuki, Kato, Takefumi, Fukaya, Naoki, Ishikawa, Hisato, Hayashi, Masatoshi, Tsuboi, Seiji, Kato, Daizo, Funahashi, Koji, Matsubara, Hiroyuki, Hattori, Yosuke, Hanabayashi, Masahiro, Hirabara, Shinya, Yoshioka, Yutaka, Ishiguro, Naoki
Format: Artikel
Sprache:eng
Schlagworte:
Abatacept
Clinical medicine
Concomitant methotrexate
Japanese patients
Medical treatment
Prior biologics
Rheumatoid arthritis
Rheumatology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Abstract Objectives The purpose of this study was to examine the treatment retention and efficacy of abatacept, the first member of a new class of biologic agents, in Japanese rheumatoid arthritis (RA) patients during clinical practice. Methods A retrospective multicenter study was conducted with patients who underwent abatacept therapy for 24 weeks (n = 143). Results Patients at baseline had a mean age of 63.5 years, a mean disease duration of 11.3 years, and a mean disease activity score in 28 joints (DAS28) of 4.5. Overall retention of abatacept treatment was 83.2 % at 24 weeks, when 46.2 % of patients achieved DAS28-defined low disease activity (LDA; DAS28
ISSN:1439-7595
1439-7609
DOI:10.3109/s10165-012-0760-4