Indirect Strong Inhibition by Acid-Stable Trypsin-Plasmin Inhibitor (ASTPI) of the Activations of Elastase and Plasma Fibrinolysis in a Dog Model of Acute Pancreatitis

Abstract Acid-stable trypsin-plasmin inhibitor (ASTPI) had almost no direct effect on the increased levels of the plasma enzymes elastase, plasmin and plasminogen activators in an acute pancreatitis model in the dog, whereas it strongly inhibited the activation of such enzymes by intravenous adminis...

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Veröffentlicht in:	Journal of enzyme inhibition 1993, Vol.7 (2), p.131-136
Hauptverfasser:	Sumi, Hiroyuki, Eto, Yasushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-stable trypsin-plasmin inhibitor Acute Disease acute pancreatitis Amino Acid Sequence Animals Biological and medical sciences Digestive system Disease Models, Animal Dogs elastase Enzyme Activation Fibrinolysin - antagonists & inhibitors Fibrinolysis - drug effects Medical sciences Molecular Sequence Data Pancreatic Elastase - antagonists & inhibitors Pancreatic Elastase - metabolism Pancreatitis - blood Pancreatitis - enzymology Pharmacology. Drug treatments plasmin plasminogen activator Trypsin Inhibitors - pharmacology
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Beschreibung
Zusammenfassung:	Abstract Acid-stable trypsin-plasmin inhibitor (ASTPI) had almost no direct effect on the increased levels of the plasma enzymes elastase, plasmin and plasminogen activators in an acute pancreatitis model in the dog, whereas it strongly inhibited the activation of such enzymes by intravenous administration. In vivo experiments also showed strong inhibition by ASTPI of pancreas tissue elastase and plasma fibrinolysis. Anti-shock and anti-pancreatitis effects of ASTPI observed in clinical therapy may be related to this "indirect inhibition".
ISSN:	1475-6366 8755-5093 1475-6374 1029-2462
DOI:	10.3109/14756369309040754