New Directions in the Biology and Therapy of Chronic Myeloid Leukemia

Great excitement surrounded the initial discovery of the Philadelphia chromosome translocation and the molecular rearrangement of the abl protooncogene which is generated by this translocation in chronic myelogenous leukemia (CML). In this review, we will discuss how molecular analysis of the biolog...

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Veröffentlicht in:	Leukemia & lymphoma 1992, Vol.6 (2), p.89-95
Hauptverfasser:	Deisseroth, Albert B., Zhang, Wei, Cha, Ying, Yuan, Tianying, Chen, Hanchun, Sims, Simon, Wedrychowski, Andrzej, Gao, Pei-Qing, Huston, Laurel, Filaccio, Marylynne, Claxton, David, Kornblau, Steven, Johnson, Elizabeth, Zack Howard, O. M., Andersson, Borje, Giglio, Auro Del, Gressot, Laurent, Kantarjian, Hagop, Talpaz, Moshe, Khouri, Issa, Champlin, Richard, Andreeff, Michael, Gaozza, Eugenia, Seong, David, Suh, Soon-Pal, Ellerson, Debra, Hu, Guiying, Chou, Marian
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology therapy of CML
Online-Zugang:	Volltext
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Zusammenfassung:	Great excitement surrounded the initial discovery of the Philadelphia chromosome translocation and the molecular rearrangement of the abl protooncogene which is generated by this translocation in chronic myelogenous leukemia (CML). In this review, we will discuss how molecular analysis of the biological abnormalities generated in the CML cells by this molecular rearrangement can be applied to new directions in therapy for this disease.
ISSN:	1042-8194 1029-2403
DOI:	10.3109/10428199209064884