Toxicology of quinone-thioethers

Abstract Cytotoxicity associated with exposure to quinones has generally been attributed to either redox cycling, and the subsequent development of "oxidative stress" and/or to their interaction with cellular nucleophiles, such as protein and non-protein sulfhydryls. Glutathione (GSH) is t...

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Veröffentlicht in:	Critical reviews in toxicology 1992, Vol.22 (5-6), p.243-270
1. Verfasser:	Monks, T.J. (The University of Texas at Austin, Austin, TX)
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BIOCHEMICAL PATHWAYS Biological and medical sciences CARCINOGENESIS CYTOTOXICITY GLUTATHIONE glutathione conjugates Humans INHIBICION INHIBITION KIDNEYS LITERATURE REVIEWS Medical sciences METABOLISM METABOLISME METABOLISMO Miscellaneous NEOPLASMAS NEOPLASME NEOPLASMS nephrocar-cinogenicity nephrotoxicity NERVOUS SYSTEM NEUROTOXICITY NEUROTOXINS OXIDACION OXIDATION Oxidation-Reduction OXYDATION PEPTIDE PEPTIDES PEPTIDOS quinines QUINONAS QUINONE quinone-thioethers QUINONES Quinones - toxicity REIN RINONES SISTEMA NERVIOSO Sulfides - toxicity SYSTEME NERVEUX TOXICIDAD TOXICITE TOXICITY TOXICOLOGIA TOXICOLOGIE TOXICOLOGY TOXINAS TOXINE TOXINS VIA BIOQUIMICA DEL METABOLISMO VOIE BIOCHIMIQUE DU METABOLISME
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